Yu-Chien Wu1,2, Andrew L. Alexander2, Ian D. Duncan3,4, Aaron S. Field4,5
1Radiology , University of Wisconsin-Madison, Madison, WI, USA; 2Waisman Laboratory for Brain Imaging & Behavior, University of Wisconsin-Madison, Madison, WI, USA; 3Medical Science, University of Wisconsin-Madison, Madison, WI, USA; 4Radiology, University of Wisconsin-Madison, Madison, WI, USA; 5Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, USA
Fractional anisotropy (FA) in the diffusion tensor imaging (DTI) is commonly used as a measure of white matter (WM) integrity. However, FA is also highly sensitive to such factors as non-Gaussian diffusion, crossing fibers and imaging noise, which may degrade its specificity. It has recently been proposed that the radial diffusivity is highly related to WM myelination. Alternatively, PDF measures in the diffusion spectrum imaging (DSI), e.g. Po and MSD, may provide additional information about WM microstructure. In this longitudinal study, the dysmyelinating shaking pup model was studied using both the DTI and DSI acquired from a hybrid diffusion imaging.
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