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Abstract #0787

Diffusion-Weighted MRI to Detect Pelvic Lymph Node Metastases in Patients with Bladder or Prostate Cancer: Comparison with Histopathology as Gold Standard

Maria Triantafyllou1, Tobias Binser2, Frederic Birkhaeuser3, Urs E. Studer3, Achim Fleischmann4, Michael Von Gunten5, Johannes M. Froehlich6, Peter Vermathen2, Harriet C. Thoeny7

1Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital Bern, Bern, Switzerland; 2Department of Clinical Research, Inselspital, Bern, Switzerland; 3Department of Urology, Inselspital, Bern, Switzerland; 4Department of Pathology, Inselpital, Bern, Switzerland; 5Department of pathology, Inselspital, Bern, Switzerland; 6Guerbet, Switzerland; 7Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital, Bern, Switzerland

The hypothesis that a decreased ADC value in lymph nodes of patients suffering from prostate or bladder cancer might indicate metastatic involvement was studied in a prospective controlled clinical study including forty patients. Hyperintense structures on b 1000 images were correlated with the morphological images to check whether these were lymph nodes. In case of an ADC value beyond 90 x 10-5 mm/sec these were classified as metastatic, while lymph nodes between 90 and 100 were ambigous. Overall a sensitivity of 80%, a specificity of 79%, a positive-predictive value of 57% and a negative predictive value of 92% resulted.