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Abstract #0788

Correlation Between Lymph Node Apparent Diffusion Coefficient and Positron Emission Tomography Standardised Uptake Value in Paediatric Patients with Lymphoma

Shonit Punwani1, Steve Bandula2, Vineet Prakash2, Alan Bainbridge2, Enrico De Vita1, Nicola Stevens2, Stuart Taylor1, Sharon Hain2, Stephen Daw2, Ananth Shankar2, Paul Humphries2

1University College London, London, UK; 2University College London Hospital, London, UK

Fluorodeoxyglucose Positron emission tomography (FDG-PET) produces images reflecting the metabolic activity of tumour tissue but imparts a significant radiation dose to the patient. Apparent diffusion coefficient (ADC) is known to be related to cellular density. In theory cellular density should be related to metabolic activity and as such ADC values could provide a potential non-ionising surrogate measure of 'functional' activity. This study aims to evaluate this relationship for lymph nodes in paediatric and adolescent patients diagnosed with lymphoma prior to treatment.