Particle Embedded Culture Dishes for Magnetic Cell Labeling

Dorit Granot¹, Erik M. Shapiro^1,2

We demonstrate a potentially standardized, sterile, reproducible and stand alone new method for magnetic cell labeling. The basic idea is a plastic cell culture dish coated with various biopolymers commonly used in cell culture in which magnetic nano- or microparticles are embedded. Adherent cells are plated on the dish, and upon attachment endocytose particles directly off the dish. As many cell types require culture either as a step in their purification, a culture vessel which includes the magnetic cell labeling step could prove useful in accelerating cell labeling times and ease, particularly in clinical environments.