Daisuke Kokuryo1, Hiroyuki Yoshida2, Kenji Kono2, Iwao Kanno1, Ichio Aoki1
1Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan; 2Graduate School of Engineering, Osaka Prefecture University, Sakai, Japan
A drug delivery system using a multimodal thermo-sensitive 'polymer-modified' liposome (MTPL) would be a powerful imaging tool to help avoid the side-effects of chemotherapy on the intact organ. In this study, an accumulation of and thermo-triggered drug release from MTPL were evaluated for disseminated-cancer using MRI and optical imaging. In the ex vivo optical images, the MTPL accumulation in the tumor area increased over 8 hours after the administration. In the T1-weighted MRI, the signal intensities in the bowel and the kidney changed after thermo-triggering.
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