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Abstract #0895

Comparison of Neutral and Charged High Density Lipoprotein Using Bimodal Nanoparticles

Torjus Skajaa1,2, Stefanie Jacoba Cornelia Geertruda Hectors1, David P. Cormode1, Nazila Kamaly3, Andrew D. Miller3,4, Wei Chen1, Alessandra Barazza5, Edward A. Fisher5, Zahi A. Fayad1, Willem J.M. Mulder1

1Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, NY, USA; 2Faculty of Health Sciences, Aarhus, Denmark; 3Department of Chemistry, Genetic Therapies Centre, Imperial College, London, UK; 4Hammersmith Hospital, London, UK; 5School of Medicine, New York University, New York, NY, USA

We here present a comparison between neutral and charged HDL like bimodal contrast agents. The particles were extensively characterized, applied on macrophages cells in vitro and on apoE-KO mice in vivo which were imaged with optical and magnetic resonance imaging.