Abstract #0895

Comparison of Neutral and Charged High Density Lipoprotein Using Bimodal Nanoparticles

Torjus Skajaa^1,2, Stefanie Jacoba Cornelia Geertruda Hectors¹, David P. Cormode¹, Nazila Kamaly³, Andrew D. Miller^3,4, Wei Chen¹, Alessandra Barazza⁵, Edward A. Fisher⁵, Zahi A. Fayad¹, Willem J.M. Mulder¹

¹Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, NY, USA; ²Faculty of Health Sciences, Aarhus, Denmark; ³Department of Chemistry, Genetic Therapies Centre, Imperial College, London, UK; ⁴Hammersmith Hospital, London, UK; ⁵School of Medicine, New York University, New York, NY, USA

We here present a comparison between neutral and charged HDL like bimodal contrast agents. The particles were extensively characterized, applied on macrophages cells in vitro and on apoE-KO mice in vivo which were imaged with optical and magnetic resonance imaging.