Willem J.M. Mulder1, Torjus Skajaa1,2, David P. Cormode1, Hans Boeve3, Zahi A. Fayad1
1Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, NY, USA; 2Faculty of Health Sciences, Aarhus, Denmark; 3Philips Research Laboratories, Eindhoven, Netherlands
Magnetic particle imaging (MPI) is a new imaging technique that has advantages for cardiac imaging. Here we present an iron oxide nanoparticle that is similar to high density lipoprotein (FeO-HDL) and can provide contrast for MRI, fluorescence techniques and MPI. We show macrophage cells to avidly take up FeO-HDL using these three imaging modalities, thereby indicating the potential of these nanoparticles in cardiovascular settings, in particular for MPI.