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Abstract #0897

A Macrophage Specific Nanoparticle Suitable for Magnetic Resonance, Fluorescence, and Magnetic Particle Imaging

Willem J.M. Mulder1, Torjus Skajaa1,2, David P. Cormode1, Hans Boeve3, Zahi A. Fayad1

1Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, NY, USA; 2Faculty of Health Sciences, Aarhus, Denmark; 3Philips Research Laboratories, Eindhoven, Netherlands

Magnetic particle imaging (MPI) is a new imaging technique that has advantages for cardiac imaging. Here we present an iron oxide nanoparticle that is similar to high density lipoprotein (FeO-HDL) and can provide contrast for MRI, fluorescence techniques and MPI. We show macrophage cells to avidly take up FeO-HDL using these three imaging modalities, thereby indicating the potential of these nanoparticles in cardiovascular settings, in particular for MPI.