Abstract #0897

A Macrophage Specific Nanoparticle Suitable for Magnetic Resonance, Fluorescence, and Magnetic Particle Imaging

Willem J.M. Mulder¹, Torjus Skajaa^1,2, David P. Cormode¹, Hans Boeve³, Zahi A. Fayad¹

¹Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, NY, USA; ²Faculty of Health Sciences, Aarhus, Denmark; ³Philips Research Laboratories, Eindhoven, Netherlands

Magnetic particle imaging (MPI) is a new imaging technique that has advantages for cardiac imaging. Here we present an iron oxide nanoparticle that is similar to high density lipoprotein (FeO-HDL) and can provide contrast for MRI, fluorescence techniques and MPI. We show macrophage cells to avidly take up FeO-HDL using these three imaging modalities, thereby indicating the potential of these nanoparticles in cardiovascular settings, in particular for MPI.