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Abstract #0898

New Fluorinated Gd-AspGlyMe-DOTA Complexes for 19F-MRI

Markus Plaumann1, Ekkehard Kstermann2, Dieter Leibfritz1

1Institute of Organic Chemistry, University of Bremen, Bremen, Germany; 2CAI, MRI/MRS, University of Bremen, Bremen, Germany

Fluorine is of interest in medical chemistry and diagnostics, because of its very low natural abundance in living organisms and high MR sensitivity. Fluorinated contrast agents allow to record 19F-images without any background signals and additional classical 1H-MR imaging at the same time. Two 3,5-Bis(trifluoromethyl)benzyl derivatives were selected as model compounds to compare ten different Gd3+-DTPA-, Gd3+-GlyMe-DOTA- and Gd3+-AspGlyMe-DOTA complexes with respect to their lipophilicity and T1-times. MRI experiments of selective molecules and ICP-MS measurements proof the possibility to label rat glioma C6 cells.