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Abstract #0899

Phase Gradient Mapping (PGM) for Positive Contrast Generation

Sunbok Lee1, Jason Langley1, Wei Liu2, Qun Zhao1,3

1Physics and Astronomy, University of Georgia, Athens, GA, USA; 2Philips research North America, Briarcliff, NY, USA; 3BioImaging Research Center, University of Georgia, Athens, GA, USA

In vivo detection of superparamagnetic iron oxide (SPIO) contrast agent can be used in many applications such as cell tracking. In this study a new post-processing method, referred to as PGM (Phase Gradient Mapping) is proposed to obtain a positive contrast image. This method measures the derivative of a phase map to detect the field inhomogeneity induced by the SIPOs susceptibility gradient. The PGM results from a phantom dataset and in vivo mouse dataset show positive contrast generated around SPIO.