Meeting Banner
Abstract #0926

Inflammation Imaging of Atherosclerosis: MRI of Iron Oxide-Labelled Macrophages Trafficking in ApoE2 (KI) Mice Lesions

Amine Bessaad1, Monica Sigovan1, Hasan Alsaid1, Genvive De Souza11, Nicolas Provost2, Zoher Majd2, Christine Menager3, Norbert Nighoghossian11, Serge Nataf4, Emmanuelle Canet-Soulas11

1Universit Lyon 1 CREATIS - LRMN, UMR CNRS 5220, U630 INSERM, Villeurbanne, Rhne, France; 2GenFit, Lille, France; 3UPMC, Paris, France; 4inserm U842, Lyon, Rhne, France

MRI caracterisation of atheroma plaque in aortic arch of mice ApoE2 (K.I) by using Anionic Magnetic Nano Particules of iron oxide labelled macrophages and assessment of inflammatory status of atheroma plaques by follow up during 3 days post-contrast, allows us to detect the macrophages after migration distributed in intimal and/or adventitial localization. this is promising for vectorization and assessement of traitement accuracy