In Vivo Differentiation of Magnetically Labeled Mesenchymal Stem Cells Into Hepatocytes for Cell Therapy to Repair Damaged Liver

Shenghong Ju¹, Gao-jun Teng¹, Haihua Lu¹

The aims of this study are to build a new in vivo model named as Iron-GFP/CCl4 model for monitoring the transdifferentiation of magnetically labeled GFP-positive MSCs into albumin-positive hepatocytes under the specific niche made by CCl4 induced persistent liver damage, and to track labeled MSCs by MR imaging in vivo in mice.