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Abstract #0950

Anatomical Phenotyping of the Knockout Mouse Model of Fragile X Syndrome

Jacob Ellegood1, Laura K. Pacey2, David R. Hampson3, Jason P. Lerch1, R Mark Henkelman1

1Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada; 2Department of Pharmacy, University of Toronto, Toronto , Ontario, Canada; 3Department of Pharmacy, University of Toronto, Toronto, Ontario, Canada

Mutations of the FMR-1 (Fragile X Mental Retardation 1) gene cause a genetic condition know as Fragile X Syndrome (FXS). The Fragile X knockout mouse is the most widely used animal model of FXS. The purpose of this study was to assess anatomical changes between Fragile X knockout and wild type mice.