Abstract #0950

Anatomical Phenotyping of the Knockout Mouse Model of Fragile X Syndrome

Jacob Ellegood¹, Laura K. Pacey², David R. Hampson³, Jason P. Lerch¹, R Mark Henkelman¹

¹Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada; ²Department of Pharmacy, University of Toronto, Toronto , Ontario, Canada; ³Department of Pharmacy, University of Toronto, Toronto, Ontario, Canada

Mutations of the FMR-1 (Fragile X Mental Retardation 1) gene cause a genetic condition know as Fragile X Syndrome (FXS). The Fragile X knockout mouse is the most widely used animal model of FXS. The purpose of this study was to assess anatomical changes between Fragile X knockout and wild type mice.