Jeff F. Dunn1,2, Cheryl R. McCreary, Andre Obenaus3, J Ross Mitchell4
1Department of Radiology, University of Calgary, Calgary, Alberta, Canada; 2Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada; 3Radiation Medicine and Radiology, Loma Linda University, USA; 4Department of Radiology, University of Calgary, Canada
Corrosion casts are a useful tool for studying the vasculature of normal, genetically altered, or diseased brain. Such casts are difficult to examine given that visual examination involves destroying the tissue surround the cast. Synchrotron-CT (X-CT) has been used for high resolution examination of the vasculature. Here we show that MRI microscopy can examine the cast structure in 3D and, combined with state of the art post-processing and visualization methods allows examination of vessels through multiple branch points to sizes of less than 60um in diameter.
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