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Abstract #0992

Accurate T1 and T2 Maps Obtained with IR-TrueFISP Calibrated by a Patient Driven Model

Ralf Berthold Loeffler1, Song Wu2, Nicole van Groningen1, Zoltan Patay1, John O. Glass1, Matthew P. Smeltzer2, Claudia Maria Hillenbrand1

1Radiological Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA; 2Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA

Quantitative IR-TrueFISP T1 and T2 maps are sensitive to variation in the RF excitation pulse. To overcome this problem we developed a model for the transformation of IR-TrueFISP derived relaxation parameters in a large patient data set toward gold standard reference signals by density-varying calibration functions fitted through a natural cubic spline. We were able to create a calibration function that transforms the IR-TrueFISP such that the fitting error between the conventional data and the IR-TrueFISP data became very small and showed almost no bias, especially for the T2 values, which are usually more error prone.