Differentiation of Oligodendroglial Genotypes Using Perfusion Weighted Imaging and Proton MR Spectroscopy

Sanjeev Chawla¹, Sangeeta Chaudhary¹, Ali Nabavizadeh¹, Sumei Wang¹, Gurpreet S. Kapoor², Gocke Timothy², Donald M. O'Rourke², Elias R. Melhem¹, Harish Poptani¹

To differentiate molecular subtypes of oligodendrogliomas, perfusion weighted imaging and multivoxel proton magnetic resonance spectroscopic imaging (1H-MRSI) were performed on 23 patients who were classified into two groups: 1p or 1p and 19q deletion (Group I), and 19q deletion only or intact alleles (Group II). Regions of oligodendrogliomas were categorized into high CBV and low CBV regions using a threshold value of 1.5 for rCBV (CBV normalized with respect to contralateral white matter). 1H-MRSI indices were computed from these regions and compared between two groups. Cho/Cr was significantly higher in-group I oligodendrogliomas from regions of high CBV only compared to group II.