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Abstract #0993

Differentiation of Oligodendroglial Genotypes Using Perfusion Weighted Imaging and Proton MR Spectroscopy

Sanjeev Chawla1, Sangeeta Chaudhary1, Ali Nabavizadeh1, Sumei Wang1, Gurpreet S. Kapoor2, Gocke Timothy2, Donald M. O'Rourke2, Elias R. Melhem1, Harish Poptani1

1Radiology, University of Pennsylvania, Philadelphia, PA, USA; 2Neurosurgery, University of Pennsylvania, Philadelphia, PA, USA

To differentiate molecular subtypes of oligodendrogliomas, perfusion weighted imaging and multivoxel proton magnetic resonance spectroscopic imaging (1H-MRSI) were performed on 23 patients who were classified into two groups: 1p or 1p and 19q deletion (Group I), and 19q deletion only or intact alleles (Group II). Regions of oligodendrogliomas were categorized into high CBV and low CBV regions using a threshold value of 1.5 for rCBV (CBV normalized with respect to contralateral white matter). 1H-MRSI indices were computed from these regions and compared between two groups. Cho/Cr was significantly higher in-group I oligodendrogliomas from regions of high CBV only compared to group II.