Abstract #1013

Avastin Alone or Combined to Campto Reduces Local Blood Oxygen Saturation in an Orthotopic Human Glioblastoma Model (U87-MG) in Nude Rats

Benjamin Lemasson^1,2, Thomas Christen^1,3, Nicolas Pannetier^1,3, Rgine Farion^1,3, Christoph Segebarth^1,4, Xavier Tizon², Peggy Provent², Philippe Genne², Emmanuel L. Barbier^1,3, Olivier Duchamp², Chantal Rmy^1,3

¹Inserm, U836, Grenoble, F-38043, France; ²Oncodesign Biotechnology, Dijon, France; ³Universit Joseph Fourier, Grenoble Institut des Neurosciences, UMR-S836, Grenoble, F-38043, France; ⁴Universit Joseph Fourier, Grenoble Institut des Neurosciences, UMR-S836, Grenoble, F-38043, France

Glioma tumors are highly angiogenic, therapies directed against tumor vasculature or preventing angiogenesis have been developed. Monitoring changes in structural and functional microvasculature should help to evaluate the efficiency of these therapies. This study shows structural (Blood Volume fraction and Vessel Size Index) and functional (Blood Brain Barrier permeability and local Blood Oxygen Saturation) modification in response to an anti-angiogenic treatment used alone or combined to a chemotherapy on an orthotopic human glioma model (U87-MG) xenografted in nude rat. lSO2 seems to be a sensitive reporter of antiangiogenic therapeutic effect and to provide independent information from BVf, VSI and BBBpem.