Eric Raymond Muir1,2, Jeromy Dooyema3, Lary C. Walker3,4, James J. Lah4,5, Timothy Q. Duong2
1Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, USA; 2Research Imaging Center, University of Texas Health Science Center, San Antonio, TX, USA; 3Yerkes National Primate Research Center, Emory University, Atlanta, GA; 4Neurology, Emory University, Atlanta, GA; 5Center for Neurodegenerative Disease, Emory University, Atlanta, GA
Alzheimer's disease is a neurodegenerative disorder characterized by a decline in memory, cognitive function and cerebrovascular dysfunction. In this study we used a presenilin-1/amyloid precursor protein (PS/APP) transgenic mouse model of AD to assess perfusion and diffusion MRI methods that could be useful in detecting and studying AD. We utilized a recently developed cardiac spin labeling (CSL) technique to image basal cerebral blood flow and hypoxia-induced blood oxygen level dependent (BOLD) and CBF changes in PS/APP mice. Additionally, diffusion tensor imaging was performed to image apparent diffusion coefficient and fractional anisotropy in PS/APP and control mice.