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Abstract #1061

Monitoring Therapy in a Triple Transgene Model of Alzheimer's DIsease Using MRS, Histology and Behavioral Correlations

Bruce G. Jenkins1, Ji-Kyung Choi1, Alpaslan G. Dedeoglu2,3

1Radiology, Massachusetts General Hospital, Charlestown, MA, USA; 2School of Medicine, Boston University, Boston, MA, USA; 3Neurology, Boston VA Hospital, Boston, MA, USA

Using a triple transgene model of AD including A-beta and tau pathology we found that treatement with the NSAID flurbiprofen produced reductions in elevated glutamine and protection of learning and tau pathology. There were significant correlations of glutamate values with learning and significant correlations of glutamine with histopathological markers of neurofibrillary tangles.