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Abstract #1087

Comparison of Quantitative MT and T2 Properties of White Matter Lesions in Alzheimer's Disease

Kimberly L. Desmond1, Greg J. Stanisz1,2, Wendy Oakden1, Nancy Lobaugh1,2

1Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; 2Imaging Research, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada

Quantitative MRI techniques have been applied in order to investigate whether white matter lesions in Alzheimers disease can be differentiated from those occurring in the normal population. In this work we compare the myelin water fraction measured with CPMG to the magnetization transfer exchange constant, R, T2b (T2 relaxation time of the semisolid pool) and M0b (semisolid pool fraction relative to bulk water) in white matter hyperintensities, as derived from a pulsed magnetization transfer experiment.