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Abstract #1092

Early Detection of Amyloid Plaques in a Transgenic Mouse Model of Alzheimer's Disease

Ryan Chamberlain1, Stephen D. Weigand2, Malgorzata Marjanska1, Denise Reyes3, Tom M. Wengenack4, Gregory Preboske3, Angela Snyder1, Geoffry L. Curran4, Christine O'Brien4, Joseph F. Poduslo4, Michael Garwood1, Clifford R. Jack3

1Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA; 2Division of Biostatistics, Mayo Clinic, Rochester, MN, USA; 3Department of Radiology, Mayo Clinic, Rochester, MN, USA; 4Departments of Neurology, Neuroscience, and Biochemistry/Molecular Biology, Mayo Clinic, Rochester, MN, USA

A novel MRI pulse sequence was used to image individual amyloid plaques two months earlier than previously reported. Eleven transgenic mice were imaged once per month from 3 to 11 months of age to determine the earliest age at which plaques can be detected. The multi-asymmetric spin-echo pulse sequence could reliably detect plaques at 7 months of age.