Abstract #1120

Dynamic Contrast Enhanced (DCE) Perfusion Indices as a Measure of Blood Brain Barrier (BBB) Disruption in Different Stages of Neurocysticercosis

Rishi Awasthi¹, Avantika Verma², Vimal Kumar Paliwal³, Sanjay Kumar Verma⁴, Kashi Nath Prasad², Ram Kishore Singh Rathore⁴, Rakesh K. Gupta¹

¹Department of Radiodiagnosis, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India; ²Department of Microbiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India; ³Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India; ⁴Department of Mathematics and Statistics, Indian Institute of Technology, Kanpur, Uttar Pradesh

DCE MRI was performed on 15 patients with Neurocysticercosis (NCC), cysts at different stages of degeneration. Various perfusion indices were analyzed and it was found that Ktrans, Kep, ve and vp were significantly high and showed positive correlation with degree of oedema in cysts with edema compared to other groups. We conclude that perfusion indices may be used to quantify degree of BBB disruption, which may be of value in understanding the mechanism of disease symptoms in future.