Nyssa Elaine Craig1, Rajiv Gandhi2, Dinesh Selvarajah2, Kar Ping Kuet, Sudheer Lankappa3, Solomon Tesfaye2, Iain David Wilkinson1
1Academic Unit of Radiology, University of Sheffield, Sheffield, South Yorkshire, UK; 2Diabetes Unit, Royal Hallamshire Hospital, Sheffield, South Yorkshire, UK; 3Academic Clinical Psychiatry, University of Sheffield, Sheffield, South Yorkshire, UK
Diabetes mellitus is a chronic multisystem disease in which poor glycaemic control leads to a myriad of complications within the body. Recent research has suggested an association between type-1 diabetes and brain parenchymal atrophy and possible cognitive decline. Eighty-seven male subjects with type-1 diabetes underwent imaging at 1.5T (30 sub-clinical, 29 painful and 28 patients with painless neuropathy). Data was pre-processed and compared using Statistical Parametric Mapping (SPM2) Voxel Based Morphometry. The sub-clinical group demonstrated greater grey and white matter probability density than painful and painless groups, and cortical CSF was also relatively greater in the painful and painless groups.