Abstract #1124

Measurement of Metabolite T2 at 3T in Niemann-Pick Disease Type C

Eva H. Baker¹, Nicole M. Yanjanin², Andrea L. Gropman³, Forbes D. Porter²

¹Diagnostic Radiology Department, Clinical Center, NIH, Bethesda, MD, USA; ²National Institute of Child Health and Development, NIH, Bethesda, MD, USA; ³Children's National Medical Center, Washington, DC, USA

This paper is part of an ongoing longitudinal study of patients with NPC that includes quantitative measurements of metabolite levels at four locations in the brain. Accurate conversion of the output of peak fitting programs into molar or molal units requires knowledge of metabolite T1 and T2 in vivo. We report T2 measurements for NAA, Cr, and Cho at 4 locations. We found that at some locations, metabolite T2 correlates with the age of the patient and severity of disease.