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Abstract #1125

Longitudinal Study of Metabolite Levels in Niemann-Pick Disease Type C

Eva H. Baker1, Nicole M. Yanjanin2, Andrea L. Gropman3, Forbes D. Porter2

1Diagnostic Radiology Department, Clinical Center, NIH, Bethesda, MD, USA; 2National Institute of Child Health and Development, NIH, Bethesda, MD, USA; 3Children's National Medical Center, Washington, DC, USA

This report is part of an ongoing longitudinal study of patients with NPC that includes quantitative measurements of metabolite levels at four locations in the brain. We have previously reported correlations of metabolite levels to patient age and disease severity. Analysis of a subset of these patients who had multiple return visits shows that similar trends can be appreciated in individual patients.