S K. Sharma1, Sanjeev Sinha1, Uma Sharma2, Karikanni Kalathil A. Danishad2, H Sharma1, H K. Misra1, H Misra1, T Kathiravan1, V V. Reddy1, Vishnubhatla Sreenivas3, S S. Kumaran2, Naranamangalam R. Jagannathan2
1Department of Medicine, All India Institute of Medcial Sciences, New Delhi, Delhi, India; 2Department of NMR and MRI Facility, All India Institute of Medcial Sciences, New Delhi, Delhi, India; 3Department of Biostatistics, All India Institute of Medcial Sciences, New Delhi, Delhi, India
Quantitative proton MRS from five brain regions (left hippocampus, temporal, frontal white/grey and occipital grey matter) of 75 obstructive sleep apnea (OSA) patients and 25 controls showed reduced tNAA in left temporal region in patients compared to controls indicating neuronal damage due to apnea. The apnea/hypopnea index (AHI) was significantly high in patients (38.829.1 events/hr) compared to controls (1.01.0 events/hr). Concentration of Cr, Cho, and Glx were similar in various brain regions studied between two groups. This may probably be due to adaptive mechanism of brain which may diminish detrimental effects of recurrent hypoxia in OSA patients.