Abstract #1128

Dynamic Changes in Brain Bioenergetics During Apneic Excursions in Obstructive Sleep Apnea

Caroline Rae¹, Delwyn Bartlett², Qiao Yang², David Walton³, Angela Denotti², Toos Sachinwalla³, Ron R. Grunstein²

¹POWMRI, University of New South Wales, Randwick, NSW, Australia; ²The University of Sydney, Australia; ³RayScan Imaging, Australia

We studied 13 males with severe, untreated OSA whilst asleep using ³¹P MRS. Hypoxic excursions (≥10% desaturation) resulted in significantly increased Pi and decreased ATP, which resolved on re-oxygenation. There were no changes in PCr or brain pH and no changes in phospho-monoesters or -diesters, and no changes in the signal from the coil phantom. These data show reversible effects on brain bioenergetics in OSA on a seconds time scale and show that sleep hypoxia with parallel loss of cerebrovascular reactivity has significant effects.