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Abstract #1129

Combining FMRI with QMRS for Understanding the Etiology of Periodic Hypersomnia

Anders Tisell1,2, Maria Engstrm1,2, Olof Dahlqvist Leinhard1,2, Thomas Karlsson3, Patrick Vigren4, Anne Marie Landtblom5, Peter Lundberg1,2

1Department of medical and health sciences, Division of radiological sciences, University of Linkoping, Linkping, Sweden; 2Center for Medical Image science and Visualization (CMIV), University of Linkoping, Linkoping, Sweden; 3Department of Behavioural Sciences and Learning, University of Linkoping, Linkoping, Sweden; 4Division of Neurosurgery, University of Linkoping, Linkoping, Sweden; 5Division of Neurology, University of Linkoping, Linkoping, Sweden

Klein Levin syndrome (KLS) is a disorder characterized by periodic hypersomnia. The etiology of KLS is unknown. In a previous study in which working memory of KLS patients was investigated using fMRI, we found an abnormal activation in left thalamus. In this work we examined the cellular metabolism in thalamus, using abso-lute quantitative MRS, hypothesizing that metabolism is coupled to the neural activa-tion in the same area. A strong correlation between the absolute NAA concentration in left thalamus and fMRI activation was found.