Abstract #1129

Combining FMRI with QMRS for Understanding the Etiology of Periodic Hypersomnia

Anders Tisell^1,2, Maria Engstrm^1,2, Olof Dahlqvist Leinhard^1,2, Thomas Karlsson³, Patrick Vigren⁴, Anne Marie Landtblom⁵, Peter Lundberg^1,2

¹Department of medical and health sciences, Division of radiological sciences, University of Linkoping, Linkping, Sweden; ²Center for Medical Image science and Visualization (CMIV), University of Linkoping, Linkoping, Sweden; ³Department of Behavioural Sciences and Learning, University of Linkoping, Linkoping, Sweden; ⁴Division of Neurosurgery, University of Linkoping, Linkoping, Sweden; ⁵Division of Neurology, University of Linkoping, Linkoping, Sweden

Klein Levin syndrome (KLS) is a disorder characterized by periodic hypersomnia. The etiology of KLS is unknown. In a previous study in which working memory of KLS patients was investigated using fMRI, we found an abnormal activation in left thalamus. In this work we examined the cellular metabolism in thalamus, using abso-lute quantitative MRS, hypothesizing that metabolism is coupled to the neural activa-tion in the same area. A strong correlation between the absolute NAA concentration in left thalamus and fMRI activation was found.