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Abstract #1142

Correlation of Metabolic and Diffusivity Markers in Multiple Sclerosis Using MR Spectroscopic Imaging and DTI

Dominic Sappey-Marinier1,2, Matthieu Bagory2, Salem Hannoun2, Danielle Ibarrola3, Jean-Christophe Comte3, Francoise Durand-Dubief2,4, Christian Confavreux4

1CERMEP-Imagerie du Vivant, Universit de Lyon, Bron, France; 2CREATIS-LRMN UMR CNRS 5220 & U630 INSERM, Universit de Lyon, Bron, France; 3IRM, CERMEP-Imagerie du Vivant, Bron, France; 4Hopital Neurologique, Groupement Hospitalier Est, Bron, France

To characterize new markers of inflammation and neurodegenerative processes in multiple sclerosis (MS), MRSI and DTI were used to study 30 MS patients and 10 control subjects. MRSI showed significant changes in metabolic ratios in between MS clinical forms and DTI fiber tracking showed significant decreases in FA and increases in ADC in semioval white matter region. Metabolic ratios are significantly correlated with diffusivity parameters as well as with the patient disability status.