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Abstract #1143

Longitudinal Imaging of Myelin Repair and Axonal Loss in Multiple Sclerosis

Robert J. Fox1, Jian Lin2, Thomas Cronin1, Xiaofeng Wang3, Ken Sakaie2, Mark J. Lowe2, Michael D. Phillips2

1Mellen Center for MS, Cleveland Clinic, Cleveland, OH, USA; 2Radiology, Cleveland Clinic, Cleveland, OH, USA; 3Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA

DTI was used to follow areas of focal inflammation (gadolinium-enhancing lesions) and normal-appearing white matter (NAWM) in 19 MS patients followed longitudinally over 1 year after starting highly-effective MS therapy. We observed increased FA in gad lesions, which was driven by a decreased in transverse diffusivity. We also observed decreased FA in NAWM, which was driven by a decrease in longitudinal diffusivity. The results are consistent with short-term remyelination within acute lesions and long-term axonal degeneration in normal appearing white matter. These results also suggest that DTI may provide pathology-specific insights into MS.