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Abstract #1150

In Vivo Measurements of Neural Stem and Progenitor Cells (NPCs) in Patients with Multiple Sclerosis and Normal Controls, Using MRS and LCModel

Claudiu Schirda1,2, Christopher Magnano1, E. Ann Yeh2, Bianca Weinstock-Guttman2, Allison S. Drake2, Jennifer L. Cox1,2, Robert Zivadinov1,2

1Buffalo Neuroimaging Analysis Center, Buffalo, NY, USA; 2Department of Neurology, The Jacobs Neurological Institute, SUNY Buffalo, Buffalo, NY, USA

Neural stem and progenitor cells (NPCs) have self-renewing capabilities, thus rendering them an attractive biomarker for monitoring repair of damaged nerve tissue. Recently, NPCs have been associated with the 1.28ppm resonance and MRS measurements in normal controls (NC) have been demonstrated, using a single value decomposition technique for quantification. We are presenting results of MRS in vivo NPCs measurements conducted in NC and multiple sclerosis (MS) patients at different ages and disease stages, using the well established LCModel to quantify the 1.28ppm biomarker.