Abstract #1185

Diffusion Tensor Fiber Tracking of Human Brain Connectivity to Localize Intractable Seizures in Epileptic Patients

Cemil Kirbas^1,2, Robert Simkins³, Phillip White³, Roulla Hilli¹, Sudeepa Gupta Hall¹, Jason Parker^1,4

¹Innovation Center, Kettering Health Network, Kettering, OH, USA; ²Psychiatry, Wright State University, Dayton, OH, USA; ³Neurology, Kettering Health Network, Kettering, OH, USA; ⁴Biomedical Engineering, Wright State University, Dayton, OH, USA

This study aimed to define abnormalities in the hippocampus and fiber tracts traversing the hippocampus to better understand the pathophysiology of temporal lobe epilepsy. While previous studies have focused on fiber tracts on fornix and cingulum, we have studied the fiber tracts traversing the whole hippocampus. A correlation between decreased FA value in the hippocampus and the presence of sclerosis was found. DTI tractography showed similar correlation with decreased number of fiber tracts traversing through the hippocampus. DTI tractography of the hippocampus could potentially be used to delineate fiber tracts connecting to the hippocampus and for pre-surgical planning.