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Abstract #1189

Pre-Surgical Mapping of Paediatric Motor Function and Structure Using Magnetoencephalography (MEG) and Diffusion Tensor Imaging (DTI)

Donald Mabbott1, Nadia Scantlebury1, Conrad Rockel1, Elysa Widjaja1, William Gaetz1

1Hospital for Sick Children, Toronto, Ontario, Canada

We investigated the clinical efficacy of using concurrent MEG-DTI methods to delineate the functional motor pathways of children seen for pre-surgical evaluation. Cortico-spinal tracts (CST) were delineated using functional and anatomical seeds in patients presenting with space-occupying lesions. Functionally-seeded tracts were more sensitive to changes in tissue micro-structure than those seeded anatomically. A significant increase in the FA, ADC and parallel diffusivity of motor-seeded, but not anatomically-seeded, CST was evident in patients relative to controls. Using motor-activated seeds to launch tracts, we characterized the displacement of CST in patients presenting with centrally-located tumors, demonstrating the validity of this technique.