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Abstract #1206

An Investigation of Intrinsic, Task-Interim Resting State BOLD Signal Correlations with Broca's and Wernicke's Areas in Schizophrenics and in Subjects at High Genetic Risk

Jeremy L. Smith1,2, Xiaobo Li2, Lynn DeLisi2, Craig A. Branch1,2

1Gruss Magnetic Resonance Research Center, Albert Einstein College of Medicine, Bronx, NY, USA; 2Medical Physics, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA

The present study demonstrates the utility of examining extracted resting state information in the context of cognitive and network architecture sequelae in schizophrenia. We examined the whole-brain correlation with Broca's and Wernicke's area BOLD signals in individual schizophrenic (SZ) patients, normative (NC) subjects, and subjects at high genetic risk (HR) for SZ. HR subjects were found to exhibit more diffuse connectivities with the two language areas than either SZ or NC subjects. Moreover, SZ and HR subjects exhibited substantial hyperconnectivity between the cerebellum and language areas. The wider implications of examining the extracted resting state BOLD signal is also discussed.