Abstract #1207

Altered Cortico-Striatal Functional Connectivity in Obsessive-Compulsive Disorder

Ben J. Harrison^1,2, Carles Soriano-Mas², Jesus Pujol², Hector Ortiz², Marina Lopez-Sola², Rosa Hernandez-Ribas², Joan Deus², Pino Alonso³, Murat Yucel¹, Christos Pantelis¹, Jose Menchon³, Narcis Cardoner³

¹Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Melbourne, Victoria, Australia; ²Institut dAlta Tecnologia-PRBB, CRC Corporaci Sanitria, Barcelona, Spain; ³Department of Psychiatry, Bellvitge University Hospital, Barcelona, Spain

Neurobiological models of obsessive-compulsive disorder (OCD) emphasize disturbances in the function and connectivity of brain cortico-striatal networks or loops. Although neuroimaging studies of OCD patients support this network model of illness, very few have applied measurements that are sensitive to brain connectivity features. In this study, we use resting-state functional magnetic resonance imaging to demonstrate that OCD is associated with disturbed functional connectivity of brain cortico-striatal networks, in particular, involving ventrolimbic cortico-striatal regions.