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Abstract #1207

Altered Cortico-Striatal Functional Connectivity in Obsessive-Compulsive Disorder

Ben J. Harrison1,2, Carles Soriano-Mas2, Jesus Pujol2, Hector Ortiz2, Marina Lopez-Sola2, Rosa Hernandez-Ribas2, Joan Deus2, Pino Alonso3, Murat Yucel1, Christos Pantelis1, Jose Menchon3, Narcis Cardoner3

1Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Melbourne, Victoria, Australia; 2Institut dAlta Tecnologia-PRBB, CRC Corporaci Sanitria, Barcelona, Spain; 3Department of Psychiatry, Bellvitge University Hospital, Barcelona, Spain

Neurobiological models of obsessive-compulsive disorder (OCD) emphasize disturbances in the function and connectivity of brain cortico-striatal networks or loops. Although neuroimaging studies of OCD patients support this network model of illness, very few have applied measurements that are sensitive to brain connectivity features. In this study, we use resting-state functional magnetic resonance imaging to demonstrate that OCD is associated with disturbed functional connectivity of brain cortico-striatal networks, in particular, involving ventrolimbic cortico-striatal regions.