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Abstract #1253

Abnormal White Matter and Gray Matter Maturation in Premature Neonates with Periventricular Hemorrhagic Infarction: A Diffusion Tensor Imaging Study

Ajay Garg1,2, Jeffrey I. Berman1, Duan Xu1, Srivathsa Veeraraghavan1, Sonia L. Bonifacio3, Hannah Cranley Glass3,4, Daniel B. Vigneron1, Anthony James Barkovich1,3, Pratik Mukherjee1

1Radiology and Biomedical Imaging, UCSF, San Francisco, CA, USA; 2Neuroradiology, AIIMS, New Delhi, India; 3Pediatrics, UCSF, San Francisco, CA, USA; 4Neurology, UCSF, San Francisco, CA, USA

We compared DTI parameters of Dav, FA, l1, l2 and l3 between preterm neonates with imaging findings of periventricular hemorrhagic infarction (PVHI) and 10 age-matched preterm healthy neonates without imaging evidence of brain injury. DTI in PVHI reveals abnormal microstructural maturation of gray matter and white matter in regions that appear normal on conventional MR imaging. Late maturing white matter regions (high- and low-centrum semiovale) and cortical regions (frontal, occipital, and temporal cortex) regions are more affected compared to earlier maturing regions such as the posterior limb of the internal capsule or the pre- and post-central cortex.