Abstract #1254

Non-Invasive Estimation of Brain Deep Grey Matter Temperature Using Localised Proton Magnetic Resonance Spectroscopy in Normothermic and Hypothermic Newborn Infants

Alan Bainbridge¹, Giles Kendall², Enrico DeVita³, Cornelia Hagmann⁴, Andrew Kapetanakis⁴, Ernest Cady³, Nicola Robertson⁴

¹Medical Physics & Bio-Engineering, UCL Hospitals NHS Foundation Trust, London , UK; ²Academic Neonatology, EGA UCL Institute for Womens Health, University College , London, UK; ³Medical Physics & Bio-Engineering, UCL Hospitals NHS Foundation Trust, London, UK; ⁴Academic Neonatology, EGA UCL Institute for Womens Health, University College, London, UK

Therapeutic cerebral hypothermia following perinatal hypoxia-ischaemia reduces both mortality and survivor neurodevelopmental disability. Precise knowledge of regional brain temperatures is needed in order to refine and optimise therapeutic hypothermia. Magnetic resonance spectroscopy thermometry (MRSt) is non-invasive and has been successfully used to measure regional brain temperature in human adults. Our aim was to assess the relation between deep brain (TDB) and rectal (Trec) temperature using MRSt in normothermic and hypothermic human neonates. The strong linear correlation between Trec and TDB suggests that MRSt can successfully measure neonatal brain temperature over a broad temperature range.