Abstract #1292

Evaluation of Hippocampal Degeneration After Prenatal Radiation Exposure Using Manganese-Enhanced MRI (MEMRI)

Shigeyoshi Saito¹, Xue-Zhi Sun², Kazuhiko Sawada³, Tetsuya Suhara⁴, Iwao Kanno⁴, Ichio Aoki⁴

¹Department of Molecular and Neuroimaging, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan; ²Regulation Science Research Group, National Institute of Radiological Sciences, Chiba, Japan; ³Laboratory of Anatomy, Department of Physical Therapy, Faculty of Medical and Health Sciences, , Japan; ⁴Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan

Radiation exposure during the prenatal period causes various diseases such as hydrocephalus and hippocampal atrophy. Our goal was to evaluate the change in volume of the manganese-enhanced hippocampal area, hippocampus and entire brain of the rat with or without X-ray exposure during the prenatal period. Our study demonstrated: 1) Atrophy of the whole brain with ventricular dilatation was observed in the radiation-exposed model; 2) The atrophy of hippocampus was confirmed by MEMRI and HE staining in the radiation exposure model; 3) The size of the manganese-enhanced area in the radiation-exposed rats increased in the hippocampus.