In Vivo 1H-MR Spectroscopy of the Mouse Cervical Spinal Cord.

Virginie Callot¹, Yann Le Fur¹, Guillaume Duhamel¹, Patrick J. Cozzone¹, Frank Kober¹

In vivo proton magnetic resonance spectroscopy (MRS) is a unique method for non invasive assessment of healthy and pathologic tissue metabolism. Spinal cord (SC) MRS has been reported in human studies, as well as in rats, however, no reports have been performed on mice although it should help, in addition to MRI, in the description of the numerous mouse models of SC diseases such as multiple sclerosis and injury. This preliminary study demonstrates the feasibility of localized 1H MRS in mouse cervical spinal cord.