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Abstract #1374

High b-Value Acquisition Using CURVE-Ball DTI

Sharon Peled1, Stephen Whalen2, Alexandra Golby2

1Radiology, Brigham and Women's Hospital, Boston, MA, USA; 2Neurosurgery, Brigham and Women's Hospital

A new strategy for obtaining high SNR high b-value DTI information in brain is presented. The basis for the approach is the independence of DTI eigenvector directions from the b-value at which the acquisition takes place. This allows determination of the eigenvectors from relatively low b-value DTI. Thus with the help of an appropriate diffusion model, diffusion curves for each eigenvector can be generated using only sparse sampling of high b-value data. The method will enable better diffusion-based tissue characterization in clinical and research settings where scan time is a limiting factor.