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Abstract #1422

Use of Fractional Anisotropy for Determination of the Cut-Off Value in 11C-Methionine Positron Emission Tomography for Glioma.

Manabu Kinoshita1, Naoya Hashimoto1, Tetsu Goto1, Takufumi Yanagisawa1, Naoki Kagawa1, Haruhiko Kishima1, Jun Hatazawa2, Toshiki Yoshimine1

1Neurosurgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan; 2Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

Assessment of biological features of malignant brain tumor by means of non-invasive image modality is required in the field of neurosurgery. Previous studies have challenged this issue by looking into individual data obtained from multimodal neuroradiological assessments. In this research, we have attempted to integrate DTI-MRI and 11C-methionine PET data to compensate each other to determine the cut-off values for discriminating normal and abnormal tissues. We believe that our findings will benefit the understanding and interpretation of malignant brain tumor imaging on DTI and 11C-methionine PET.