Abstract #1459

Cingulum Bundle Asymmetry Predicts Trait Neuroticism: A DTI Study

Kathrine Skak Madsen^1,2, Terry L. Jernigan^1,2, Arnold Skimminge^1,3, Erik Lykke Mortensen^2,4, Gitte M. Knudsen^2,5, William F.C. Baar^1,2

¹Danish Research Center for Magnetic Resonance, Copenhagen University Hospital, Hvidovre, Copenhagen, Denmark; ²Center for Integrated Molecular Brain Imaging, Copenhagen, Denmark; ³DTU Informatics, Technical University of Denmark, Lyngby, Denmark; ⁴Department of Health Psychology, University of Copenhagen, Copenhagen, Denmark; ⁵Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark

Amygdala and subgenual cingulate are linked to anxiety and mood disorders, for which the trait neuroticism is a risk factor. Left and right subgenual cingulate functional imbalances may contribute to behavioural and physical symptoms observed in depression. We investigated associations between neuroticism and cingulum FA in 45 healthy adults. DWI images were processed with TBSS to align main fibre tracts and ROIs were drawn in right and left cingulum. As hypothesized, cingulum FA laterality index (asymmetry) significantly predicted neuroticism. It is unclear whether cingulum FA asymmetry is a possible marker of increased risk of developing anxiety and mood disorders.