Abstract #1460

High Resolution Diffusion-Weighted Imaging Showing Radial Anisotropy in the Human Cortex in Vivo

Robin Martin Heidemann¹, Alfred Anwander¹, Thomas R. Knsche¹, Thorsten Feiweier², Fabrizio Fasano^3,4, Josef Pfeuffer⁵, Robert Turner¹

¹Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; ²Siemens Healthcare Sector, Erlangen, Germany; ³Fondazione Santa Lucia, Rome, Italy; ⁴Siemens Medical Solutions, Milano, Italy; ⁵Siemens Medical Solutions, Charlestown, MA, USA

High resolution diffusion-weighted imaging is affected by blurring due to T₂* relaxation and geometrical distortions due to off-resonance effects. A combination of a zoomed approach and parallel imaging enables one to achieve high acceleration factors which are essential to obtain high resolution diffusionweighted images with minimal distortions. With the achieved image quality and an in plane resolution of 1 mm x 1 mm it is possible to show the radial anisotropy of the human cortex in vivo.