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Abstract #1461

Gender Differences in Correlations of Regional White Matter Integrity with Intelligence Factor Scores

Johnny Ng1, CheukYing Tang1,2, Emily Eaves1, Isabella Kanellopoulou2, Xinsu Mai1, David Carpenter1, David Schroeder3, Roberto Colom4, Richard J. Haire3,5

1Radiology, Mount Sinai School of Medicine, New York, NY, USA; 2Psychiatry, Mount Sinai School of Medicine, New York, NY, USA; 3Johnson O'Connor Research Foundation, Chicago, IL, USA; 4Universidad Autónoma de Madrid (UAM), Spain; 5School of Medicine, UC Irvine, Irvine, CA, USA

We studied correlations between regional white matter integrity, using DTI with a Siemens 3T Allegra, and intelligence factor scores with gender effect in 40 control subjects. Fractional anisotropy (FA) and directional color maps were computed using in-house software. Region of Interests were defined on color-coded maps. FA values were extracted and merged with intelligence factor scores for correlation analysis. Significant positive and negative correlations were detected. These findings were consistent with a recent report on DTI/IQ correlations on subjects 5-18 where correlations were negative in males and positive in females as they aged. Our results confirmed these findings into adulthood.