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Abstract #1467

Estimation of CBF Values Using Multi-Echo DSC-MRI: a Comparison with a Xenon CT

Matus Straka1, Greg Zaharchuk1, Rexford David Newbould2, Gregory W. Albers3, Michael E. Moseley1, Roland Bammer1

1Lucas Center, Department of Radiology, Stanford University, Stanford, CA, USA; 2GlaxoSmithKline, London, UK; 3Stroke Center, Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA

Standard PWI acquisitions using single-echo EPI suffer from various errors (e.g. vascular signal clipping and counfound determination of quantitative perfusion values). Advanced acquisition schemes (e.g. PERMEATE) as well as corrections for partial volume effect and susceptibility effect of tracers in bulk blood were proposed to mitigate the problems. In this study, we have compared CBF perfusion maps computed from multi-echo parallel EPI sequences with values from XeCT CBF maps. We conclude that multi-echo acquisition contribute to better estimates of the quantitative parameter, but the improved acquisition opened a whole new set of challenges that were important before.