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Abstract #1469

Dynamic Susceptibility MRI with a Pre-Bolus Administration Design for Improved Absolute Quantification of Perfusion

Linda Knutsson1, Anna Rydhg1, Danielle van Westen2, Stig Holts2, Freddy Sthlberg2,3, Ronnie Wirestam1

1Department of Medical Radiation Physics, Lund University, Lund, Sweden; 2Department of Diagnostic Radiology, Lund University, Lund, Sweden; 3Department of Medical Radiation Physics, Lund University , Lund, Sweden

Reproducible absolute quantification of cerebral blood volume (CBV) and cerebral blood flow (CBF) by dynamic susceptibility contrast MRI (DSC-MRI) is difficult to achieve, for example, due to partial-volume effects (PVEs). The purpose of this study was to correct for arterial PVEs by rescaling the AIF using a VOF obtained by injecting a fraction of the contrast-agent dose as a pre-bolus. During the pre-bolus passage, a segmented EPI sequence in single-slice mode was used to register the VOF in the superior sagittal sinus. Our results showed that our proposed correction method removed a substantial amount of arterial PVEs.