Dose Optimization for Combined Perfusion Weighed Imaging and Contrast Enhanced MRA Using Gadofosveset

Erik Sndergaard Poulsen¹, Aage Kristian Olsen², Dora Zeidler¹, Niels Hjort¹, Leif stergaard¹

We optimized the dose of novel Gd-based, intravascular contrast agent gadofosveset trisodium (Vasovist, Bayer Schering Pharma. Berlin, Germany) for dynamic susceptibility contrast (DSC) MRI in the brain. In 40 kg anesthetized pigs, a dose of 0.0916 mmol/kg was shown to generate a similar signal drop as a standard 0.1 mmol/kg Gd-chelate (Gadovist 1.0, Bayer Schering Pharma. Berlin, Germany) while generating good CNR on steady state MRA.