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Abstract #1471

Dose Optimization for Combined Perfusion Weighed Imaging and Contrast Enhanced MRA Using Gadofosveset

Erik Sndergaard Poulsen1, Aage Kristian Olsen2, Dora Zeidler1, Niels Hjort1, Leif stergaard1

1Center of Functionally Integrative Neuroscience (CFIN), University of Aarhus, Aarhus, Denmark; 2PET-center, Aarhus University Hospital, Denmark

We optimized the dose of novel Gd-based, intravascular contrast agent gadofosveset trisodium (Vasovist, Bayer Schering Pharma. Berlin, Germany) for dynamic susceptibility contrast (DSC) MRI in the brain. In 40 kg anesthetized pigs, a dose of 0.0916 mmol/kg was shown to generate a similar signal drop as a standard 0.1 mmol/kg Gd-chelate (Gadovist 1.0, Bayer Schering Pharma. Berlin, Germany) while generating good CNR on steady state MRA.