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Abstract #1472

Quantification of Vessel Permeability by Modeling Contrast Agent Extravasation in Dynamic Susceptibility Contrast MRI of Brain Tumors

Yi-Ying Wu1, Wei-Shan Yang2,3, Yuan-Yu Hsu4, Ho-Ling Liu2,5

1Institute of Medical Physics and Imaging Science, Chang Gung University, Kwei-Shan , Tao-Yuan, Taiwan; 2Institute of Medical Physics and Imaging Science, Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan; 3Department of Radiology, Cheng Hsin Rehabilitation Medical Center, Taipei, Taiwan; 4Department of Medical Imaging, Buddhist Tzu Chi General Hospital, Taipei, Taiwan; 5MRI Center, Chang Gung Memorial Hospital, Tao-Yuan, Taiwan

Disruption of BBB in brain tumors can cause errors in perfusion measurements using DSC MRI. This study proposed a model that takes both T1 and T2 effect of the contrast extravasations into account and at the same time incorporates the parameter of permeability-surface-area-product (PS). This model was applied in three DSC datasets of brain tumors at 3T. The resultant PS ranged from 0.28 to 0.74 min-1 in tumors, which was greater than in normal tissues. Tumor/white matter blood volume ratios were corrected (3.5-7.4 before and 1.6-4.4 after correction) by fitting DSC time curves to the proposed model.