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Abstract #1473

Quantitative OEF Determination in Tumor Patients Using Additional DSC Measurements

Moritz Mie1, Maja Sohlin2, Johann Scharf3, Lothar Rudi Schad4

1Computer Assisted Clinical Medicine, Faculty of Medicine Mannheim,, University of Heidelberg, Mannheim, Germany; 2Medical Physics in Radiology, DKFZ, Heidelberg, Germany; 3Department of Neuroradiology, University Hospital, Mannheim, Germany; 4Computer Assisted Clinical Medicine, Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany

Tissue oxygenation is a very important factor in the field of neuroradiology. With the assistance of the oxygen extraction fraction (OEF) an estimation of tissue viability should be possible. In this work, we improved the present technique by using an additional independent dynamic susceptibility contrast (DSC) measurement that directly gives the amount of cerebral blood volume (CBV) which is an important parameter for stabilizing the OEF calculation. With this technique a difference in OEF between a healthy brain area and a tumorous one is observed.