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Abstract #1474

Normative Blood Flow Values in the Posterior Fossa Using Quantitative Spin-Echo DSC Perfusion MRI

Jessy J. Mouannes1, Anahita Aghaei-Lasboo2, Amir H. Yassari3, Anindya Sen2, Aaron Skolnik3, Shahram Rahimi2, Timothy J. Carroll2,4, Bernard R. Bendok5, Matthew T. Walker2, Sandra W. Horowitz2, Ali Shaibani2

1Biomedical Engineering, Northwestern University , Chicago, IL, USA; 2Radiology, Northwestern University, Chicago, IL, USA; 3Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; 4Biomedical Engineering, Northwestern University, Chicago, IL, USA; 5Neurological Surgery, Northwestern University, Chicago, IL, USA

The interest in cerebral perfusion imaging has increased in recent years, with the aim of accurately detecting brain tissue at risk of infarction. These efforts have resulted in the establishment of normal values for cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time (MTT), for the supratentorial section of the brain. However, without a quantitative understanding of normal flow values in the posterior fossa, it is difficult to make judgments on issues such as cerebrovascular reserve or chronic ischemia. Therefore, we have evaluated normative quantitative perfusion values for the posterior fossa in adults using the Bookend technique.