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Abstract #1477

Gas-Filled Microbubbles as Intravascular Susceptibility Contrast Agent for Brain MRI

Jerry S. Cheung1,2, April M. Chow1,2, Ed X. Wu1,2

1Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong SAR, China; 2Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong SAR, China

Gas-filled microbubbles have the potential to become a unique MR contrast agent due to their magnetic susceptibility effect, biocompatibility and localized manipulation via ultrasound cavitation. In this study, custom-made albumin-coated microbubbles and a commercially available lipid-based clinical ultrasound contrast agent SonoVue were investigated with in vivo dynamic brain MRI in Sprague-Dawley rats at 7 Tesla. The results indicate that microbubbles can serve as an intravascular contrast agent for brain MRI at high field. Such microbubble MRI has the potential to provide real-time MRI guidance in various microbubble-based drug delivery and therapeutic applications.